Product Details
Place of Origin: China
Brand Name: DropBrigt® FLA
Certification: HALA
Model Number: ≥ 99% powder
Payment & Shipping Terms
Minimum Order Quantity: 25kg
Packaging Details: 25kg/bucket
Delivery Time: Goods in stock
Supply Ability: Negotiable
Appearance: |
Off-white Crystalline Powder |
Assay: |
≥ 99.0 % |
Melting Point: |
170-175℃ |
Loss On Drying: |
≤ 0.5% |
Sulfated Ash: |
≤ 0.1% |
Appearance: |
Off-white Crystalline Powder |
Assay: |
≥ 99.0 % |
Melting Point: |
170-175℃ |
Loss On Drying: |
≤ 0.5% |
Sulfated Ash: |
≤ 0.1% |
Anti Inflammatory FLA Ferulic Acid Powder Cas 1135-24-6
DropBrigt® FLA (Ferulic Acid )is widely found in plants in nature, in plants in Ferula, Angelica Sinensis, ligusticum Chuanxiong, equisetum and other traditional Chinese medicine.
(Ferulic Acid structural formula)
Ferulic acid exists in a very small amount in free form in plants. Most of it binds to Lignin, polysaccharides and proteins in cells through Ester and ether bonds to form the CYTOSKELETON.
Ferulic Acid is a potent phenolic antioxidant with antioxidant properties. It can scavenge free radicals and promote the synthesis of enzymes such as Quinone reductase and Glutathione. In the field of cosmetics, ferulic acid can effectively resist ultraviolet radiation, but also inhibit the activity of the Melanin Enzyme and Melanocytes, anti-wrinkle, anti-aging, whitening, anti-inflammation and other effects, whitening skin care products is an important raw material.
Human Epidermal melanocytes were treated with different concentrations of FLA solution, and the proliferation activity of melanocytes was determined. The results showed that after FLA treatment for 24,48 and 72 hours, the proliferation of Melanin was inhibited, the higher the concentration was, the stronger the inhibitory effect was, and the longer the action time was, the stronger the inhibitory effect was.
|
group |
24h |
48h |
72h |
|
blank group |
1.982±0.115 |
1.776±0.052 |
1.632±0.540 |
|
0.01mg/mL |
1.558±0.106 |
1.590±0.108 |
1.453±0.023 |
|
0.10mg/mL |
1.570±0.006 |
1.462±0.026 |
1.291±0.024 |
|
1.00mg/mL |
1.320±0.021 |
1.242±0.022 |
1.060±0.035 |
Conlusion:FLA has a strong antioxidant effect, can inhibit the formation of lysine enzyme, inhibit the activity of melanocytes, reduce the production of Melanin.
Ultraviolet radiation can activate NF-κb signal, which is induced by Keratinocyte kinase 2(CK2) . Inhibition of CK2 is thought to have anti-inflammatory effects.
The experiment showed that about 30 μmol/L Fla could directly phosphorylate about 80% of the enzyme, and inhibited CK2-induced phosphorylation of the enzyme in a dose-dependent manner. The results showed that FLA could inhibit the activation of NF-κb by inhibiting the phosphorylation of CK2 to reduce the inflammation induced by UV irradiation. NF-κb is a transcription factor associated with inflammation.
| Product Name | DropBrigt® FLA |
| INCI Name | Ferulic Acid |
| CAS No. | 1135-24-6 |
| Appearance | Off-white crystalline powder |
| Assay(HPLC) | ≥ 99.0% |
| Supplier | Drop(Nanjing)Bio-Tech Co.,Ltd. |
| Recommended Applications | Cosmetic Ingredients |
