GLUCONOLACTONE GDL Second Generation Fruit Acid CAS 90-80-2 Cosmetics Raw Material Moisturize Light Aging Resistant

GLUCONOLACTONE GDL Second Generation Fruit Acid CAS 90-80-2 Raw Material Of Cosmetics Moisturize Light Aging Resistance

DropCare^® Gluco L

GLUCONOLACTONE

The second generation of alpha hydroxy acids, also known as polyhydroxyacids (PHAs), are carboxylic acids with multiple hydroxyl groups, mostly in the form of lactones, represented by gluconolactone. Glucolactone is an ester formed by dehydration between the carboxyl group of glucose acid and the hydroxyl group in the molecule, and between the hydroxyl group on the fifth carbon atom (δ position), which is called gluconate-δ-lactone. "An ester formed by dehydration of the hydroxyl group on the fourth (γ-position) carbon atom, called gluconate-γ-lactone."

Gluconic acid does not have the function of acidic groups in the lactone state, and it has the structure of AHAs when it is transformed into gluconic acid in the skin, which is less irritating than the first generation of AHAs. In addition, more hydroxyl groups make it have good water absorption ability, which can play an excellent moisturizing effect.

The mechanism of photoaging: when ultraviolet irradiation on the skin surface, it will increase the abnormal elastin in the skin. These abnormal and bad structural elastin will accumulate in the skin and cause the degeneration of elastic fibers. Conclusions: UV radiation damages the skin through a variety of mechanisms, including the generation of free radicals. Glucolactone is a polyhydroxy acid (PHA), which can chelate metal ions and also protect the skin from ultraviolet (UV) radiation damage by scavenging free radicals.

Glucolactone can provide skin protection by blocking UV short wavelengths in an in vitro system, but UV absorption spectra showed that only about 50% protection was provided by glucolactone against induction of the elastin promoter. This suggests that about 50% of UV-induced damage may be caused by free radical formation, whereas other mechanisms, such as direct DNA damage, are responsible for UV-induced skin damage.